Depression May Differ Based on Sex


Dr. Marianne Seney, pic
Dr. Marianne Seney

An experienced psychiatrist, Dr. Carol Lynn Childers serves as a consultant physician at both Trilogy Behavioral Healthcare and Healthcare Alternative Systems in Chicago. Dr. Carol Lynn Childers serves patients with serious illnesses that may include severe depression.

According to a study recently published in the journal Behavioral Psychiatry, the genetic changes associated with depression may differ significantly between male and female patients. The study was performed at the University of Pittsburgh School of Medicine, where a team of researchers evaluated 50 postmortem brain tissue samples from individuals who had depression, 24 men and 26 women.

Under the guidance of study author Dr. Marianne Seney, the research team identified genes that expressed differently in women and men who had the same diagnosis. Only 21 genes were altered in the same way in both men and women, while 52 genes showed changes in both sexes but in opposing directions.

For example, men with depression showed a reduction in the expression of genes related to synapse function, while women with depression had an increase in the expression of those same genes. The research team has noted that these findings suggest a contrasting pathology in men and women who have depression. In time and with a more detailed understanding of the processes, this information may lead to different treatments for depression in men and women.


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